TEL AVIV: Israeli researchers report that they have invented the first fully personalized tissue implant, engineered from a patient’s own materials and cells. The new technology makes it possible to engineer any kind of tissue implant, for the spinal cord, to the heart, or brain, from one small fatty tissue biopsy.
“We were able to create a personalized hydrogel from the materials of the biopsy, to differentiate fatty tissue cells into different cell types and to engineer cardiac, spinal cord, cortical and other tissue implants to treat different diseases,” said lead researcher Prof. Tal Dvir of Tel Aviv University’s Center for Nanoscience and Nanotechnology and Sagol Center for Regenerative Biotechnology.
“Since both the cells and the material used derive from the patient, the implant does not provoke an immune response, ensuring proper regeneration of the defected organ,” Dvir explained.
The research was conducted by Dvir’s postdoctoral researcher, Reuven Edri, and doctoral students Nadav Noor and Idan Gal, in collaboration with Prof. Dan Peer and Prof. Irit Gat Viks of TAU’s Department of Cell Research and Immunology and Prof. Lior Heller of Assaf HaRofeh Medical Center in Israel. It was recently published in the journal Advanced Materials.
“With our technology, we can engineer any tissue type, and after transplantation, we can efficiently regenerate any diseased or injured organ — a heart after a heart attack, a brain after trauma or with Parkinson’s disease, a spinal cord after injury,” said Dvir.
“In addition, we can engineer adipogenic [fatty tissue] implants for reconstructive surgeries or cosmetics. These implants will not be rejected by the body.”- Israel21c
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